| 2022-04-21 20:00:58April 21, 2022 |   Guelph @ St. Catharines | 6 - 3 | Bill Burgoyne Memorial Arena |
| 2022-04-23 15:00:21April 23, 2022 |  Wallaceburg vs Guelph | 9 - 11 | Victoria Road Arena |
| 2022-04-29 20:00:51April 29, 2022 |  Hamilton vs Guelph | 7 - 8 | Victoria Road Arena |
| 2022-05-06 20:00:14May 6, 2022 |  Welland vs Guelph | 7 - 18 | Victoria Road Arena |
| 2022-05-07 19:00:08May 7, 2022 |  Guelph @ Windsor | 5 - 12 | Forest Glade Arena |
| 2022-05-11 20:00:14May 11, 2022 |  Elora vs Guelph | 9 - 6 | Victoria Road Arena |
| 2022-05-13 20:00:15May 13, 2022 | St. Catharines vs Guelph | 11 - 9 | Victoria Road Arena |
| 2022-05-15 15:00:02May 15, 2022 | Windsor vs Guelph | 11 - 10 | Victoria Road Arena |
| 2022-05-19 20:00:33May 19, 2022 |  Guelph @ Owen Sound | 15 - 13 | Harry Lumley Bayshore Community Centre |
| 2022-05-20 20:00:39May 20, 2022 |  Guelph @ Six Nations | 6 - 12 | Iroquois Lacrosse Arena |
| 2022-05-25 20:00:36May 25, 2022 | Owen Sound vs Guelph | 7 - 14 | Victoria Road Arena |
| 2022-05-28 19:00:21May 28, 2022 | Guelph @ Wallaceburg | 12 - 5 | Wallaceburg Memorial Arena |
| 2022-05-29 15:00:04May 29, 2022 |  Guelph @ Pt. Edward | 11 - 6 | Point Edward Arena |
| 2022-06-03 20:00:50June 3, 2022 |  Guelph @ London | 19 - 5 | Lambeth Arena |
| 2022-06-05 19:00:07June 5, 2022 | Guelph @ Elora | 4 - 8 | Elora & District Community Centre |
| 2022-06-08 20:00:45June 8, 2022 | Pt. Edward vs Guelph | 20:00:458:00 pm | Victoria Road Arena |
| 2022-06-09 20:00:30June 9, 2022 | Guelph @ Hamilton | 20:00:308:00 pm | Valley Park Community Centre |
| 2022-06-12 15:00:21June 12, 2022 | Six Nations vs Guelph | 15:00:213:00 pm | Victoria Road Arena |
| 2022-06-15 20:00:07June 15, 2022 | London vs Guelph | 20:00:078:00 pm | Victoria Road Arena |
| 2022-06-19 19:00:51June 19, 2022 | Guelph @ Welland | 19:00:517:00 pm | Welland Main Arena |
