| 2019-04-24 20:00:52April 24, 2019 |   Elora vs Guelph | 7 - 7 | Victoria Road Arena |
| 2019-04-27 19:00:12April 27, 2019 |  Guelph @ Windsor | 1 - 4 | Forest Glade Arena |
| 2019-04-28 19:00:03April 28, 2019 |  Guelph @ St. Catharines | 7 - 10 | Thorold Community Arenas |
| 2019-05-02 20:00:11May 2, 2019 |  Guelph @ Owen Sound | 8 - 10 | Harry Lumley Bayshore Community Centre |
| 2019-05-03 20:00:52May 3, 2019 |  Welland vs Guelph | 9 - 17 | Victoria Road Arena |
| 2019-05-05 15:00:40May 5, 2019 | Windsor vs Guelph | 7 - 10 | Victoria Road Arena |
| 2019-05-09 20:00:15May 9, 2019 |  Guelph @ Hamilton | 4 - 9 | Dave Andreychuk Mountain Arena |
| 2019-05-11 19:00:15May 11, 2019 |  Wallaceburg vs Guelph | 6 - 11 | Victoria Road Arena |
| 2019-05-12 19:00:07May 12, 2019 | Guelph @ Elora | 10 - 12 | Elora & District Community Centre |
| 2019-05-17 20:00:01May 17, 2019 | Owen Sound vs Guelph | 20:00:018:00 pm | Victoria Road Arena |
| 2019-05-19 15:00:04May 19, 2019 |  Six Nations vs Guelph | 15:00:043:00 pm | Victoria Road Arena |
| 2019-05-23 20:00:14May 23, 2019 |  Guelph @ London | 20:00:148:00 pm | Lambeth Arena |
| 2019-05-24 20:00:59May 24, 2019 |  NOTL vs Guelph | 20:00:598:00 pm | Victoria Road Arena |
| 2019-05-26 16:00:02May 26, 2019 | Guelph @ Wallaceburg | 16:00:024:00 pm | Wallaceburg Memorial Arena |
| 2019-05-31 20:00:58May 31, 2019 | Guelph @ Six Nations | 20:00:588:00 pm | Iroquois Lacrosse Arena |
| 2019-06-02 15:00:02June 2, 2019 | St. Catharines vs Guelph | 15:00:023:00 pm | Victoria Road Arena |
| 2019-06-05 20:00:11June 5, 2019 | London vs Guelph | 20:00:118:00 pm | Victoria Road Arena |
| 2019-06-07 20:00:56June 7, 2019 | Hamilton vs Guelph | 20:00:568:00 pm | Victoria Road Arena |
| 2019-06-09 19:00:10June 9, 2019 | Guelph @ Welland | 19:00:107:00 pm | Welland Main Arena |
| 2019-06-15 19:00:06June 15, 2019 |  Guelph @ Pt. Edward | 19:00:067:00 pm | Point Edward Arena |
